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. 2010 Jan 29;6(1):e1000658. doi: 10.1371/journal.pcbi.1000658

Figure 2. Simulated effects of sex hormones on cardiac action potentials.

Figure 2

The APD for each concentration of sex-steroid hormone is indicated for the 50th paced beat at a cycle length of 1000 ms in single M-cells. (A)–(B) Simulated APD in the presence of E2 (0.1 and 1 nM) and progesterone (2.5 and 40.6 nM) compared to control condition (0 nM). (C) Simulated APD with combined effects of E2 and progesterone at three physiological concentrations corresponding to different stages of the menstrual cycle: early follicular phase (estrogen: 0.1 nM and progesterone: 2.5 nM), late follicular phase (estrogen: 1 nM and progesterone: 2.5 nM) and luteal phase (estrogen: 0.7 nM and progesterone: 40.6 nM). (D) Simulated effects of two physiological concentrations of testosterone (10 and 35 nM) on APD. The corresponding APD at 90% repolarization (APD90) is shown in horizontal bar graphs (right panels).