Table 2. High dosage of GCN5 and SPT8 partially suppress the Ts⁻ phenotypes of replication factor mutants.

	High dosage gene	Growth at 23°C	Growth at 37°C
orc2-1	No episome	++++	−
	Control	++++	−
	GCN5	++++	++
	SPT8	++++	++
	SPT16	++++	−
	POB3	++++	−
orc5-1	No episome	++++	−
	Control	++++	−
	GCN5	++++	++
	SPT8	++++	++
	SPT16	++++	−
	POB3	++++	−
mcm5-461	No episome	++++	+/−
	Control	++++	+/−
	GCN5	++++	+++
	SPT8	++++	+++
	SPT16	++++	+/−
	POB3	++++	+/−

orc2-1, orc5-1 and mcm5-461 cell were transformed with high copy episomes (2 µm) carrying the shown genes and then grown at 23°C or 37°C. Growth was assessed by size of colony after 3 days at 23°C or after 5 days at 37°C.