Figure 5. Survey of morphologic variation of DCX-expressing progenitor cells and immature neurons in the DG of a young human subject (5 years-old).

Increasing cellular differentiation (dendrites and axons) can be observed starting from the hilar polymorphic layer/subgranular layer (PML/SGL) throughout the GCL up to the inner molecular layer. However, undifferentiated round-shaped cells were always found throughout the entire GCL. This picture is a montage of DCX labeled granule cell and sorted increasingly maturated from left to right. Dendrites are directed towards the granule cell layer (top) and the axons towards the hilus (bottom). Scale bar, 10 µm.