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. 2010 Jan 29;5(1):e8955. doi: 10.1371/journal.pone.0008955

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Sanz et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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AKI was induced by a single folic acid overdose. This model is characterized by increased renal tubular expression of TWEAK and Fn14 [9], [10]. A) RelB immunohistochemistry, B) p52 immunohistochemistry. Note nuclear cell localization of RelB and p52 in mice with acute kidney injury (AKI) at 24 h (arrows). TWEAK deficiency or antibody mediated inhibition decreases RelB and p52 positive nuclei. Controls for the technique are stained with non-specific IgG. Original magnification ×400. Detail ×1000. Pictures representative of 5 animals per group.