Table 3.
The association of presence of PVI with DFS, among all patients and for subgroups defined by hormone receptor status
| DFS hazard ratio (95% CI) for effect of PVI presence : absence |
||
| Trial VIII (premenopausal) | Trial IX (postmenopausal) | |
| All patients | 1.61 (1.20–2.10); P = 0.0001 | 1.27 (1.04–1.50); P = 0.02 |
| Hormone receptor statusa | ||
| Present | 1.83 (1.38–2.43) | 1.19 (0.95–1.49) |
| Absent | 1.08 (0.63–1.84) | 1.54 (1.01–2.38) |
a
There was heterogeneity in the association of PVI with DFS according to hormone receptor status: trial VIII, P = 0.04 for interaction; trial IX, P = 0.02 for interaction.
PVI, peritumoral vascular invasion; DFS, disease-free survival; CI, confidence interval.