Appendix 2:

Dosing during the first 10 cycles of treatment

Cycle	Docetaxel				Capecitabine				Bevacizumab
	N	Median total dose administered	Median dose level administered	Full dose received	N	Median total dose administered	Median dose level administered	Full dose received	N	Median total dose administered	Median dose level administered	Full dose received
		mg	mg/m2	%		mg	mg/m2	%		mg	mg/m2	%
1	45	136	75	100	45	36 400	825	98	45	1100	15	100
2	40	126	75	58	40	33 650	825	60	41	1084	15	100
3	36	120	60	47	36	32 200	660	44	37	1050	15	100
4	32	120	60	47	28	28 950	660	25	33	1010	15	100
5	31	120	60	45	26	31 625	660	23	32	1005	15	100
6	27	115	60	44	22	31 625	660	23	29	1000	15	100
7	22	117	62	45	19	28 000	660	26	23	1074	15	96
8	18	115	62	44	16	28 000	660	19	22	1060	15	95
9	14	119	62	43	13	32 200	660	23	18	1084	15	94
10	13	117	60	38	12	30 100	660	25	18	1084	15	94