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Current/voltage (I/V) relationships for WT-IKs and mutant (IAP54-56-IKs) channels. (A) Activating IKs as a function of voltage, normalized to cell surface area and measured at the end of a 5-sec depolarizing pulse. (B) Normalized tail current amplitude at -40 mV as a function of depolarizing potential. Fits to Boltzmann distributions are shown. (C) Time constant of IKs activation as a function of voltage. Time constants of IKs deactivation as a function of voltage are shown in (D).
