. Author manuscript; available in PMC: 2011 Jan 1.

Published in final edited form as: J Mol Cell Cardiol. 2009 Jul 30;48(1):181. doi: 10.1016/j.yjmcc.2009.07.020

Table 2.

The effects of KCNQ1 mutant IAP54-56, WT NPPA peptide fragment and mutant NPPA S64R peptide fragment on I_Ks properties.

	n	Activating I_Ks(pA/pF, +20 mV)	I_Ks tail (pA/pF)	V_1/2(mV)	τ_-activation(ms, +20 mV)	τ_{-deactivation}(ms, -40 mV)
Control-1	7	25.2±5.1	18.9±45	23.9±2.6	1864.2±143.3	552.7±60.3
IAP54-56-I_Ks	8	75.1±8.2 ^†	36.4±6.1 ^†	2.6±0.8 ^†	987.4±127.5 ^†	334.5±38.6 ^†
Control-2	7	23.2±7.7	17.2±2.6	21.7±2.4	1859.8±125.7	564.5±53.2
WT NPPA fragment	7	53.1±9.2 ^‡	30.3±4.2 ^‡	10.6±1.3 ^‡	1448.8±106.4 ^*	414.9±37.5 ^*
*Mutant NPPA* S64R fragment**	7	77.9±9.7 ^‡,^∥	46.2±5.9 ^‡,^∥	0.8±1.1 ^‡,^∥	850.3±83.1 ^‡,^∥	307.7±30.5 ^‡,^§

Values are shown as mean±SEM; The activating I_Ks was elicited with 5-sec pulsing to +20 mV from a holding potential of -80 mV and the I_Ks tail was recorded upon pulsing back to -40 mV;

P<0.05 vs. control-2

^†

P<0.001 vs. control-1

^‡

P<0.001 vs. control-2

^§

P<0.05 vs. WT NPPA peptide fragment

^∥

P<0.001 vs. WT NPPA peptide fragment; there was no statistical difference between two control groups.