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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Mol Carcinog. 2010 Feb;49(2):166–174. doi: 10.1002/mc.20586

Fig. 2. Location of two novel non-synonymous polymorphisms identified in WRN.

Fig. 2

(A) L628V results from a C to G transversion in exon 16 of the WRN helicase domain. Amino acid sequence comparisons of the helicase regions of other RecQ-family DNA helicases indicate that L628 is a poorly conserved residue. (B) P204L results from a C to T transition in exon 6 of the WRN exonuclease domain. Amino acid sequence comparisons of WRN exonuclease homologues show that the proline at this position is strictly conserved.