Table 1.
Associations (P values) of NPSR1 SNPs with motor function phenotypes in all study participants.
| N | rs2609234 | rs714588 | rs1963499 | rs2168890 | rs2530547 | rs887020 | rs1379928 | rs323917 | rs323922 | rs324377 | hopo546333 | rs324396 | rs10278663 | rs740347 | rs324981 | rs727162 | rs6972158 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Allele tested | A | A | A | G | C | G | T | G | C | A | T | T | A | C | A | G | G | |
|
Gastrointestinal transit | ||||||||||||||||||
| Log(GE T ½) | 268 | .675 | .928 | .254 | .200 | .733 | .713 | .282 | nt | .770 | .780 | .565 | .122 | .885 | .119 | .884 | .719 | .512 |
| CF6 | 219 | .877 | .528 | .818 | .996 | .630 | .827 | .912 | nt | .057 | .080 | .303 | .846 | .004 | .052 | .104 | .219 | .322 |
| Log(GC24) | 172 | .055 | .469 | .486 | .423 | .922 | .947 | .002 | nt | .196 | .239 | .104 | .970 | .783 | .007 | .480 | .475 | .035 |
| Log(GC48) | 171 | .0002 | .071 | .220 | .068 | .678 | .493 | .006 | nt | .395 | .344 | .337 | .777 | .485 | .026 | .728 | .072 | .009 |
|
Satiation | ||||||||||||||||||
| Log(MT Vol) | 116 | .175 | .826 | .821 | .430 | .831 | .374 | .839 | nt | .838 | .838 | nt | .943 | .648 | .928 | .538 | .839 | .971 |
| Aggregate Score | 116 | .392 | .245 | .830 | .094 | .198 | .182 | .108 | nt | .442 | .274 | nt | .935 | .953 | .780 | .011 | .456 | .018 |
|
Gastric Volume and Accommodation | ||||||||||||||||||
| Log(Fast GVol) | 228 | .269 | .316 | .449 | .375 | .132 | .693 | .559 | nt | .290 | .162 | .881 | .956 | .637 | .873 | .087 | .979 | .990 |
| Log(Av Fed GVol) | 228 | .892 | .410 | .881 | .879 | .361 | .519 | .865 | nt | .305 | .384 | .344 | .330 | .420 | .135 | .026 | .303 | .944 |
| Delta Vol | 228 | .685 | .783 | .457 | .615 | .954 | .663 | .709 | nt | .777 | .906 | .160 | .277 | .283 | .090 | .220 | .195 | .935 |
NOTE: GE T ½ = gastric half emptying time; CF6 = colonic filling at 6 hours; GC24/GC48 = colonic geometric center at 24/48 hours; MT Vol = maximum tolerated volume; Aggregate Score = aggregate score of postprandial symptoms (nausea, fullness, bloating, pain); Fast GVol = fasting gastric volume; Av Fed GVol = average feeding gastric volume; Delta Vol = Fast GVol - Av Fed GVol; nt = not tested (allele frequency below 0.05). Significant P values (< 0.05) are reported in bold, and are underlined when significant even after False Discovery Rate (FDR) correction for the multiple tests performed.