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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: J Mol Cell Cardiol. 2009 Oct 24;48(2):395. doi: 10.1016/j.yjmcc.2009.10.004

Figure 1.

Figure 1

Palmitate alters sarcomere mechanics in a concentration-dependent manner. (A) Representative recordings of sarcomere shortening in adult (wild type mouse) ventricular myocytes recorded stimulated at 1Hz and during superfusion with control Tyrode solution or Tyrode solution containing BSA (top panel) or palmitate: BSA (lower panel). (B) Single contraction record obtained from the experiment in (A) during exposure to control Tyrode and to palmitate:BSA, immediately prior to washout. (C) Although BSA has no measurable effects on contractility, exposure to palmitate:BSA significantly (P < 0.05; paired t-test),reduced mean ± SEM (n = 28) fractional shortening in a concentration-dependent manner (D). *Values are significantly (P < 0.05) different from controls.