Table 3.

Diet-induced obesity study: body weights, daily food intake and plasma chemistries.

Variable	DR	Control	DIO
Group size	12	11	12
Body weight (grams)
Initial	297 ± 1	300 ± 1	302 ± 2
Final	512 ± 3	510 ± 3	589 ± 4*
Food Consumption (kcal/day)
Weeks 0-2	98 ± 2	103 ± 2	116 ± 2*
Weeks 2-6	97 ± 2	97 ± 1	114 ± 2*
Fat Pads (grams)†	27.8 ± 1.7	20.3 ± 1.2	36.8 ± 2.3
Plasma Glucose (μmol/ml)	10.6 ± 0.6	10.9 ± 0.4	11.2 ± 0.8
Plasma Insulin (ng/ml)	7.8 ± 1.9	7.4 ± 2.3	17.3 ± 3.7*
Insulin/Glucose Ratio (ng/μmol)	0.73 ± 0.17	0.65 ±018	1.63 ± 0.38*
Plasma Leptin (ng/ml)	4.0 ± 0.6	1.3 ± 0.2**	5.1 ± 0.5

Data are means ± sem. DR, diet-resistant rats; Control, chow-fed rats; DIO, diet-induced obese rats. Fat pads weighed were: epididymal, mesenteric and retroperitoneal.

^*P < 0.05 differs significantly from either DR or control values

^†P < 0.05, any group comparison significantly different

^**P < 0.05, differs significantly from either DR or DIO values (ANOVA, Tukey test).