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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Neuropharmacology. 2009 Sep 16;58(2):436. doi: 10.1016/j.neuropharm.2009.09.007

Figure 1.

Figure 1

A. Cocaine exposure significantly reduces uptake of exogenous 3H-dopamine in explants of E15 mouse striatum. Cocaine does not produce significant changes in this measurement in explants of E15 cerebral cortex. B. Dopamine produces dose-dependent increases in cAMP levels in explants of cerebral cortex and striatum obtained from E15 mice. Maximal cAMP levels are induced at a dopamine concentration of 10µM (10−5M) in both tissue samples.