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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Neuropharmacology. 2009 Sep 16;58(2):436. doi: 10.1016/j.neuropharm.2009.09.007

Figure 4.

Figure 4

Basal cAMP level and its modulation by dopamine D1- and adenosine A2a receptor antagonists in samples of the cerebral cortex (A) and striatum of E15 saline- or cocaine-exposed embryos. Basal (unstimulated) cAMP levels are significantly elevated in the cerebral cortex and striatum of cocaine-exposed embryos compared to the saline-exposed controls. A2a receptor antagonist Schering 58261 decreases the basal levels in the cerebral cortex of the cocaine-exposed embryos such that the levels are not statistically different from the basal levels seen in the saline-exposed controls. The D1-receptor antagonist Schering 23390 does not affect the basal levels in the cortex. Neither Schering58261 nor Schering 23390 has statistically significant effects on basal cAMP levels in the cocaine-exposed striatum.