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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Neuropharmacology. 2009 Sep 16;58(2):436. doi: 10.1016/j.neuropharm.2009.09.007

Figure 6.

Figure 6

Dopamine D2- and adenosine A2a-receptor interactions in the cerebral cortex (A) and striatum (B) of E15 saline-exposed (control) embryos. Periodate-oxidized adenosine (PAD) significantly increased cAMP levels in both the cerebral cortex and the striatum. PAD-induced increase in cAMP was blocked in the presence of the A2a antagonist Schering58261 in both the regions. The selective A2a agonist CGS21680 produced significant increases in cAMP levels and the increase was blocked by the A2a antagonist Schering21680 as well as by the D2-receptor agonist TNPA in both the brain regions.