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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Mol Carcinog. 2010 Feb;49(2):152–156. doi: 10.1002/mc.20584

Figure 2. Inactivation of E2f2 enhances proliferation in K5.Myc transgenic epidermis.

Figure 2

(A) BrdU incorporation in the epidermis was analyzed by immunohistochemical staining of skin sections from wild type (E2f2+/+), E2f2−/−, K5.Myc, and K5.Myc, E2f2−/− mice. The percentage of BrdU-positive cells in the epidermis was calculated from at least four mice for each genotype. * indicates a statistically significant difference between K5.Myc, E2f2+/+ and K5.Myc, E2f2−/− mice as determined by the student’s paired t-test (p < 0.05). (B) Skin sections from the same mice used above were stained for the activated form of caspase 3 as an indicator of apoptosis. The average number of caspase 3-positive cells per 10 mm of linear epidermis was determined for each genotype.