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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Neuropharmacology. 2009 Sep 13;58(2):501. doi: 10.1016/j.neuropharm.2009.08.022

Table 3.

The effect of CXCL12 on sIPSC and sEPSC characteristics in 5-HT and non-5-HT neurons. sIPSC characteristics before (baseline) and after CXCL12 (10 nM) application are presented for 5-HT (A) and non-5-HT (B) cells. sEPSC characteristics before (baseline) and after CXCL12 (10 nM) application are presented for 5-HT (C) cells.

Treatment Frequency (Hz) Amplitude (pA) Rise 10–90% (ms) Fast decay (ms) Slow decay (ms)
A sIPSC characteristics in 5-HT DRN neurons
Baseline 10.3 ± 1.1 14.8 ± 2.0 1.6 ± 0.1 3.0 ± 0.4 12.0 ± 2.0
+CXCL 12 15.0 ± 1.7** 15.2 ± 1.8 1.8 ± 0.1 4.3 ± 1.0 11.2 ± 3.0
B sIPSC characteristics in non 5-HT DRN neurons
Baseline 11.0 ± 1.7 22.4 ± 2.9 1.5 ± 0.1 3.2 ± 0.5 17.7 ± 5.6
+CXCL 12 11.5 ± 2.0 31.5 ± 5.5* 1.4 ± 0.2 2.7 ± 0.3 13.2 ± 5.4
Treatment Frequency (Hz) Amplitude (pA) Rise 10–90% (ms) Decay (ms)
C sEPSC characteristics in 5-HT DRN neurons
Baseline 6.1 ± 0.5 12.8 ± 0.4 1.5 ± 0.1 2.7 ± 0.1
+CXCL 12 7.5 ± 0.6* 12.2 ± 0.3 1.5 ± 0.1 2.9 ± 0.1
*

= p < 0.05

**

= p < 0.01 by paired Student’s t-test comparing baseline vs. CXCL12 treatment groups.

All values are mean ± SEM except for Rise 10-90% which is median ± SEM.