Fig. 3.
Collagen fiber diameter is affected by over expression of soluble DDR1/ECD and DDR2/ECD in the ECM of cultured cell lines. The average fiber diameters for both DDR1/ECD and DDR2/ECD samples are notably smaller than the nontransfected samples (NT). ‘d’ is the average diameter (nm) obtained by measuring 200 fibers from each sample type after two weeks of culture. The fiber cross-sections of DDR1/ECD and DDR2/ECD display fused fibers (arrow) while the nontransfected samples show characteristic circular cross-sections (arrow). Magnification of micrographs is 50,000x.