Table 3. Selected 9p21 SNPs associated with PMI based logistic regression model.

			Minor Allele Frequency		Covariate-adjusted additive genetic model*
SNP	Chr 9 position	Allele (Minor/Major)	Cases	Controls	Odds Ratio (95% CI)	Asymptotic P-value †	FWER permuted P-value ‡	Prior non-surgical MI studies
rs10116277	22,071,397	G/T	0.53	0.40	1.79 (1.29 - 2.51)	0.001	0.019	(7)
rs6475606	22,071,850	C/T	0.53	0.40	1.79 (1.28 - 2.50)	0.001	0.020
rs1333040	22,073,404	C/T	0.46	0.33	1.66 (1.20, 2.28)	0.002	0.054	(7)
rs2383206	22,105,026	A/G	0.50	0.38	1.67 (1.20, 2.32)	0.002	0.061	(2)
rs2383207	22,105,959	A/G	0.50	0.37	1.71 (1.23 - 2.38)	0.001	0.040	(7)
rs10757278	22,114,477	A/G	0.54	0.42	1.70 (1.22 - 2.38)	0.001	0.052	(7)

Six most significant SNPs by asymptotic P-value selected. For entire SNP list, see supplement table 1.

SNP, single nucleotide polymorphism; Chr, chromosome; FWER, family-wise error rate; CI, confidence interval; MI, myocardial infarction

^*The cohort-specific clinical model consists of predictors from the multivariable model in Table 2.

^†Asymptotic P-value covariate adjusted

^‡Family-wise empirical P value is used to adjust for multiple comparisons.