Table 1.

Characteristics of the animal groups. Data represent mean ± SEM. Data were analyzed by 2-factor ANOVA with Bonferroni post-tests. Factors were diet (NF or HF) and glycemia status (STZ-treated or vehicle). NF = normal-fat diet, HF = high-fat diet, Veh = vehicle-treated, STZ = streptozotocin-treated. NS = non-significant. * p < 0.05, ** p < 0.01 compared to NF at same glucose status.

					FACTOR EFFECT (p)
Parameter	NF Veh	HF Veh	NF STZ	HF STZ	Diet	Glucose status	Interaction
Age at sacrifice (days)	168 ± 4	166 ± 3	167 ± 4	162 ± 1	NS	NS	NS
Days on diet	115 ± 4	113 ± 3	114 ± 4	109 ± 1	NS	NS	NS
Weight at sacrifice (g)	575 ± 21	673 ± 21 **	570 ± 15	647 ± 19 *	< 0.001	NS	NS
Weight gain on diet (g)	312 ± 16	404 ± 16 **	306 ± 15	387 ± 18 **	< 0.001	NS	NS
Glucose (mM)	82 ± 2	89 ± 3	87 ± 4	99 ± 4 *	0.004	0.025	NS
Insulin (ng/ml)	6.1 ± 1.3	8.7 ± 1.2	6.0 ± 1.1	7.4 ± 0.5	NS	NS	NS
Insulin × Glucose	502 ± 115	799 ± 127	533 ± 103	728 ± 60	0.03	NS	NS
n	9	11	8	8