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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: J Mol Cell Cardiol. 2009 Aug 7;48(1):172. doi: 10.1016/j.yjmcc.2009.07.028

Figure 6. Simulation of vagal stimulation in presence and absence of Na current.

Figure 6

A–C. Spontaneous APs under control conditions (gray) and with 4x background K conductance (black) without any added Na current (top), with Na current equivalent to that in adult SAN cells (middle) and with Na current of newborn SAN cells (bottom). Control cycle length (CL) was 307 ms with or without Na current addition. With 4x K conductance, CL increased to 380 and 379 ms with no INa or AD INa but to only 360 ms with NB INa. D–F. Spontaneous APs under control conditions (gray) and with 5x background K conductance (black) with the same 3 levels of Na current. With the higher K conductance, spontaneous activity ceased except in the case of NB INa, where CL=422 ms.