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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Atherosclerosis. 2009 Jul 23;208(1):104. doi: 10.1016/j.atherosclerosis.2009.07.029

Fig. 1.

Fig. 1

Effects of EFV, gingkolide B and MnTBAP on endothelial monolayer permeability in HCAECs. Endothelial monolayer permeability was tested with a transwell system and a Texas Red labeled dextran tracer. (A) Concentration-dependent study. HCAECs were treated with increasing concentrations of EFV (1, 5 and 10 µg/ml) or with TNF-α (2 ng/ml) as a positive control for 24 hrs. Ginkgolide B (50 µM) was used to block EFV-induced endothelial permeability. (B) MnTBAP (a SOD mimetic antioxidant) effectively blocked EFV-induced endothelial permeability. HCAECs were treated with 5 µg/ml EFV in the presence of 2 µM MnTBAP for 24 hrs. n = 3, *P < 0.05. **P < 0.01.