Table 2.
Progestagen group | No (%) of cases (n=448*) | No (%) of controls (n=1728*) | Unadjusted odds ratios by interview data (95% CI) | Unadjusted odds ratios by GP record data (95% CI) | Unadjusted odds ratios by data combined (95% CI)† |
---|---|---|---|---|---|
No oral contraception | 386 (86.7) | 1467 (85.0) | 1.00 | 1.00 | 1.00 |
2nd and 3rd generation | 40 (9.2) | 180 (10.7) | 0.79 (0.53 to 1.16) | 0.75 (0.50 to 1.11) | 0.78 (0.52 to 1.18) |
2nd generation | 20 (4.5) | 119 (7.1) | 0.58 (0.35 to 0.98) | 0.78 (0.47 to 1.29) | 0.73 (0.43 to 1.25) |
Norethisterone | 2 (0.4) | 14 (0.8) | 0.49 (0.11 to 2.23) | 1.53 (0.39 to 5.97) | 1.25 (0.25 to 6.19) |
Levonorgestrel | 18 (4.0) | 105 (6.1) | 0.59 (0.34 to 1.03) | 0.72 (0.42 to 1.23) | 0.69 (0.39 to 1.22) |
3rd generation | 20 (4.5) | 61 (3.5) | 1.20 (0.7. to 2.06) | 0.71 (0.40 to 1.24) | 0.85 (0.48 to 1.51) |
Gestodene | 11 (2.5) | 24 (1.4) | 1.72 (0.82 to 3.62) | 1.10 (0.51 to 2.35) | 1.33 (0.61 to 2.89) |
Desogestrel | 9 (2.0) | 37 (2.1) | 0.86 (0.41 to 1.84) | 0.48 (0.22 to 1.09) | 0.58 (0.25 to 1.31) |
Progestagen only | 9 (2.0) | 49 (2.8) | 0.69 (0.34 to 1.43) | 0.80 (0.44 to 1.43) | 0.80 (0.41 to 1.55) |
No information on oral contraceptive use obtained from three cases and two controls. There were 10 index women and 30 controls taking other oral contraceptives: type unknown, norgestimate, high dose oestrogen (50 mg mestranol), or cyproterone (interview data).
With interview data when disagreement on current exposure or not, GP record data when disagreement on type of oral contraceptive.