Table 3.
Multivariable-adjusted prevalence odds ratios for surgically-diagnosed endometriosis and adenomyosis according to baseline reproductive and hormonal characteristics in the California Teachers Study
| |
Endometriosis during study 1995-2003 |
Adenomyosis during study 1995-2003 |
||||
|---|---|---|---|---|---|---|
| No endometriosis | Endometriosis | Multivariable adjusted POR (95% CI)*a | No adenomyosis | Adenomyosis | Multivariable adjusted POR (95% CI)*b | |
| Pregnancy history | ||||||
| Never pregnant | 10554 | 79 | 1.0 | 16831 | 116 | 1.0 |
| Ever pregnant, no full-term pregnancy | 3711 | 20 | 0.65 (0.40, 1.07) | 4965 | 50 | 1.30 (0.93, 1.81) |
| At least one full-term pregnancy | 28543 | 130 | 0.52 (0.39, 0.70) | 55711 | 791 | 1.78 (1.46, 2.17) |
|
Ptrend |
|
|
<.001 |
|
|
<.001 |
| Number of full-term pregnancies and age at first | ||||||
| Nulliparous | 14265 | 99 | 1.22 (0.88, 1.68) | 21802 | 166 | 0.68 (0.55, 0.83) |
| 1-2 full-term pregnancies, first at age <25 years | 4052 | 25 | 0.98 (0.61, 1.56) | 8846 | 186 | 1.68 (1.37, 2.06) |
| 1-2 full-term pregnancies, first at age 25-29 years | 9789 | 62 | 1.0 | 16258 | 206 | 1.0 |
| 1-2 full-term pregnancies, first at age ≥30 years | 8467 | 31 | 0.54 (0.35, 0.84) | 12716 | 145 | 0.83 (0.67, 1.03) |
| ≥3 full-term pregnancies, first at age <25 years | 2506 | 7 | 0.43 (0.20, 0.94) | 9027 | 159 | 1.56 (1.25, 1.93) |
| ≥3 full-term pregnancies, first at age ≥25 years |
3729 |
5 |
0.20 (0.08, 0.50) |
8858 |
95 |
0.90 (0.70, 1.15) |
| Ever had difficulty becoming pregnant | ||||||
| No | 35181 | 183 | 1.0 | 63007 | 750 | 1.0 |
| Yes | 7372 | 45 | 1.17 (0.84, 1.62) | 13863 | 201 | 1.11 (0.95, 1.31) |
| Unknown |
255 |
1 |
|
637 |
6 |
|
| Ever used fertility drugs for pregnancy | ||||||
| No | 40129 | 214 | 1.0 | 74002 | 900 | 1.0 |
| Yes |
2679 |
15 |
1.05 (0.62, 1.79) |
3505 |
57 |
1.16 (0.88, 1.53) |
| Ever breastfedc | ||||||
| No | 6680 | 37 | 1.0 | 15963 | 225 | 1.0 |
| Yes |
25574 |
113 |
0.72 (0.43, 1.20) |
44713 |
616 |
0.74 (0.62, 0.88) |
| Ever had tubal ligation | ||||||
| No | 36806 | 205 | 1.0 | 66342 | 732 | 1.0 |
| Yes | 5630 | 21 | 0.66 (0.42, 1.04) | 10234 | 212 | 1.57 (1.34, 1.84) |
| Unknown |
372 |
3 |
1.50 (0.48, 4.71) |
931 |
13 |
1.31 (0.75, 2.28) |
| Oral contraceptive use | ||||||
| No | 6565 | 35 | 1.0 | 21819 | 175 | 1.0 |
| Yes, past user | 29427 | 179 | 1.17 (0.81, 1.69) | 47947 | 718 | 1.54 (1.28, 1.85) |
| Yes, current user | 5967 | 13 | 0.41 (0.21, 0.78) | 6479 | 47 | 1.08 (0.76, 1.51) |
| Unknown |
849 |
2 |
|
1262 |
17 |
|
| Menopausal status | ||||||
| Premenopausal | 42808 | 229 | 42862 | 624 | 4.72 (3.22, 6.91) | |
| Perimenopausal | - | 2269 | 32 | 3.40 (2.10, 5.51) | ||
| Postmenopausal, no hormone therapy use | - | 11349 | 43 | 1.0 | ||
| Postmenopausal, estrogen use only | - | 3330 | 25 | 2.09 (1.27, 3.43) | ||
| Postmenopausal, estrogen plus progestin use only | - | 13853 | 163 | 2.87 (2.04, 4.02) | ||
| Postmenopausal, mixed hormone therapy use | - | 3560 | 69 | 4.93 (3.37, 7.21) | ||
| Postmenopausal, unknown hormone therapy use |
|
|
- |
284 |
1 |
0.92 (0.13, 6.73) |
| Body mass index (kg/m2) | ||||||
| Underweight (<18.5) | 1335 | 6 | 0.86 (0.38, 1.96) | 2159 | 12 | 0.53 (0.30, 0.95) |
| Normal weight (18.5-24.9) | 26946 | 140 | 1.0 | 45036 | 501 | 1.0 |
| Overweight (25-29.9) | 8531 | 55 | 1.26 (0.92, 1.72) | 17770 | 258 | 1.30 (1.11, 1.51) |
| Obese (≥30) | 5224 | 23 | 0.83 (0.53, 1.29) | 10112 | 162 | 1.35 (1.12, 1.62) |
| Unknown | 772 | 5 | 2430 | 24 | ||
| Ptrend | .86 | <.001 | ||||
*
POR, prevalence odds ratio; CI, confidence interval.
a
Adjusted for age, race, family history of endometriosis, time to regular menstrual periods, and length of menstrual cycle.
b
Adjusted for age, race, age at menarche, time to regular menstrual periods, and length of menstrual cycle.
c
Among parous women.