Table 6.
Docetaxel PK in patients treated with 30 mg/m2 in the presence of PI-88 compared with PK in patients treated with docetaxel alone
| PK parameters | Docetaxel + PI-88 (n = 11) |
Docetaxel alonea (n = 8) |
|---|---|---|
| Cmax (nM) | 931 ± 347 | 933 ± 372 |
| AUC (nM h) | 1,390 ± 396 | 1,446 ± 494 |
| t1/2α (h) | 0.11 ± 0.04 | 0.08 ± 0.03 |
| t1/2β (h) | 1.24 ± 0.53 | 0.88 ± 0.49 |
| t1/2γ (h) | 33.0 ± 18.4 | 25.4 ± 20.1 |
| CL (L/h/m2) | 29.3 ± 10.7 | 29.1 ± 11.9 |
| Vss (L/m2) | 434 ± 358 | 322 ± 330 |
PK parameters calculated using a three-compartment model
a
Docetaxel alone data are from Gustafson et al. [20]