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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2009 Oct 15;30(1):113. doi: 10.1161/ATVBAHA.109.196550

Figure 1.

Figure 1

An overview of the cholesterol synthesis from squalene. Intermediate reactions from lanosterol to desmosterol and lathosterol in the Bloch pathway and Kandutsch-Russell pathway respectively are not shown. Sterol-C5-desaturase-like (SC5DL) converts lathosterol into 7-dehydrocholesterol. The 24-dehydrocholesterol reductase (DHCR24) catalyzes the reduction of the delta-24 double bond of sterol intermediates in the Bloch pathway forming a sterol which is part of the Kandutsch-Russell pathway. DHCR24 also catalyzes the formation of cholesterol from desmosterol.