Table 1.
Study characteristics of the normolipidemic relatives (NLR) and patients with familial combined hyperlipidemia (FCH) in the population at large and by gender.
| All Subjects | Men | Women | |||||||
|---|---|---|---|---|---|---|---|---|---|
| NLR | FCH | % difference |
NLR | FCH | % difference |
NLR | FCH | % difference |
|
| N | 240 | 103 | - | 117 | 45 | - | 123 | 58 | - |
| Age, years | 44 (15) | 51 (15) | 16* | 44 (14) | 52 (12) | 18* | 44 (15) | 50 (17) | 14‡ |
| BMI, kg/m2 | 25 (3) | 29 (4) | 16* | 25.5 (3.3) | 28.8 (3.5) | 13* | 24.8 (3.5) | 28.5 (4.6) | 15* |
| WHR | 0.87 (0.08) | 0.91 (0.08) | 5† | 0.92 (0.07) | 0.97 (0.04) | 5* | 0.83 (0.06) | 0.86 (0.06) | 4‡ |
| Glucose, mmol/L | 4.8 [4.5, 5.2] | 5.1 [4.6, 5.6] | 6† | 4.9 [4.6, 5.3] | 5.4 [5.0, 5.9] | 10‡ | 4.6 [4.4, 5.0] | 4.9 [4.4, 5.3] | 7‡ |
| Insulin, µU/mL | 5.9 [4.1, 8.1] | 8.8 [6.8, 12.4] | 49* | 6.3 [3.9, 8.3] | 8.7 [6.1, 9.5] | 38† | 5.8 [4.2, 7.8] | 8.9 [7.4, 13.0] | 53* |
| Triglycerides, mmol/L | 1.2 [0.9, 1.6] | 2.9 [2.0, 4.1] | 142* | 1.4 [1.0, 1.8] | 3.4 [2.7, 4.8] | 143* | 1.1 [0.8, 1.3] | 2.5 [1.7, 3.2] | 127* |
| Total cholesterol | 5.2 (1.0) | 6.9 (1.2) | 33* | 5.4 (0.9) | 7.0 (1.2) | 30* | 5.1 (0.9) | 6.8 (1.2) | 33* |
| HDL-C, mmol/L | 1.3 (0.3) | 1.1 (0.3) | −15* | 1.2 (0.3) | 1.0 (0.2) | −17* | 1.4 (0.3) | 1.3 (0.2) | −7* |
| LDL-C, mmol/L | 3.5 (0.9) | 4.2 (1.2) | 20* | 3.7 (0.9) | 3.9 (1.3) | 5 | 3.3 (0.9) | 4.4 (1.1) | 33* |
| Non HDL-C, mmol/L | 3.9 (0.9) | 5.7 (1.2) | 46* | 4.2 (0.9) | 6.0 (1.1) | 43* | 3.7 (0.9) | 5.5 (1.2) | 49* |
| VLDL-C, mmol/L | 0.4 [0.2, 0.6] | 1.1 [0.7, 1.9] | 175* | 0.5 [0.3, 0.7] | 1.5 [1.1, 2.5] | 200* | 0.3 [0.2, 0.5] | 0.9 [0.6, 1.7] | 200* |
| VLDL-TG, mmol/L | 0.7 (0.4, 1.0) | 2.2 (1.3, 3.2) | 214* | 0.9 [0.6, 1.2] | 2.7 [2.1, 4.2] | 200* | 0.6 [0.3, 0.8] | 1.6 [1.0, 2.6] | 167* |
| sdLDL-C, mg/dL | 37 (19) | 57 (27) | 54* | 48 (19) | 50 (24) | 4 | 30 (14) | 60 (27) | 100* |
| RLPC, mmol/L | 6 (4, 10) | 20 (12, 35) | 233* | 8 [5, 12] | 29 [19, 53] | 263* | 5 [4, 8] | 16 [9, 26] | 220* |
| ApoB, mg/L | 960 (221) | 1371 (256) | 43* | 1026 (214) | 1372 (198) | 34* | 898 (210) | 1371 (294) | 53* |
| ApoB48, mg/dL | 0.4 [0.2, 0.6] | 0.8 [0.5, 1.6] | 100* | 0.4 [0.3, 0.6] | 1.4 [1.0, 1.8] | 250* | 0.3 [0.2, 0.5] | 0.7 [0.4, 1.1] | 133* |
Values are mean (sd) or median [inter quartile range].
*
p<0.001,
†
p<0.01,
‡
p<0.05.
P values were adjusted for age and family structure. Due to limited sample availability Insulin, sdLDL-C, RLPC and ApoB48 were measured in 269 subjects.