Table 4.
Cholesterol absorption markers, expressed in absolute concentrations as well as normalized to total cholesterol, in the normolipidemic relatives (NLR) and patients with familial combined hyperlipidemia (FCH)
| NLR | FCH | % difference FCH vs. NLR |
p value† | BMI adj. p value‡ |
|
|---|---|---|---|---|---|
| Sterols expressed in µmol/L | |||||
| Campesterol | |||||
| Total | 9.7 [7.1, 13.2] | 11.0 [7.8, 15.3] | 13 | 0.191 | 0.022 |
| Men | 10.2 [7.7, 14.2] | 12.3 [9.7, 17.3] | 21 | 0.065 | 0.012 |
| Women | 9.1 [6.8, 12.3]* | 9.5 [7.1, 13.0]* | 4 | 0.726 | 0.243 |
| Sitosterol | |||||
| Total | 6.2 [4.7, 8.1] | 7.1 [4.7, 10.1] | 15 | 0.167 | 0.006 |
| Men | 6.2 [4.9, 8.3] | 7.5 [5.5, 10.4] | 21 | 0.131 | 0.027 |
| Women | 6.2 [4.6, 8.0] | 6.1 [4.5, 9.5] | −2 | 0.571 | 0.068 |
| Cholestanol | |||||
| Total | 7.8 (2.8) | 8.1 (3.0) | 4 | 0.387 | 0.303 |
| Men | 8.3 (3.1) | 8.3 (2.3) | 0 | 0.912 | 0.887 |
| Women | 7.3 (2.4)* | 7.9 (3.4) | 8 | 0.180 | 0.125 |
| Sterols expressed as 102 mmol/mol cholesterol | |||||
| Campesterol/C | |||||
| Total | 203 [155, 264] | 169 [135, 241] | −17 | 0.011 | 0.302 |
| Men | 200 [152, 286] | 181 [158, 273] | −10 | 0.839 | 0.369 |
| Women | 207 [158, 259] | 154 [113, 211]† | −26 | 0.003 | 0.052 |
| Sitosterol/C | |||||
| Total | 128 [98, 165] | 109 [82, 152] | −15 | 0.004 | 0.396 |
| Men | 121 [96, 157] | 119 [86, 163] | −2 | 0.347 | 0.710 |
| Women | 135 [100, 170] | 101 [78, 148] | −25 | 0.004 | 0.164 |
| Cholestanol/C | |||||
| Total | 160 (53) | 134 (48) | −16 | 0.001 | 0.010 |
| Men | 162 (56) | 135 (40) | −17 | 0.030 | 0.067 |
| Women | 158 (50) | 133 (53) | −16 | 0.015 | 0.059 |
*
Significantly different from men at p < 0.05 within the subgroup.
†
P values adjusted for age and family structure.
‡
P values adjusted for age and family structure and BMI.