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. Author manuscript; available in PMC: 2011 Jan 15.
Published in final edited form as: Biochem Biophys Res Commun. 2009 Dec 23;391(3):1459. doi: 10.1016/j.bbrc.2009.12.094

Fig. 2.

Fig. 2

Farnesyltransferase inhibitor and statin prevented LPS-induced cleavage of caspase-3 in the liver (A) and spleen (B). At 18 h after LPS injection, the liver and spleen were excised under anesthesia. Immunoblot analysis (IB) revealed that LPS induced cleavage of caspase-3. Both simvastatin and farnesyltransferase inhibitor, FTI-277, decreased cleavage of caspase-3 in LPS-administered mice, as compared with vehicle. β-Actin expression was not altered by LPS or the inhibitors. *p<0.05, **p<0.01, ***p<0.001 vs without LPS, ##p<0.02 vs LPS + vehicle, §p<0.05, §§p<0.01 vs LPS + vehicle.