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. Author manuscript; available in PMC: 2011 Jan 15.
Published in final edited form as: Biochem Biophys Res Commun. 2009 Dec 23;391(3):1459. doi: 10.1016/j.bbrc.2009.12.094

Fig. 4.

Fig. 4

LPS-induced phosphorylation of JNK/SAPK and c-Jun were attenuated by statin and farnesyltransferase inhibitor in the liver. To assess the effects on JNK/SAPK activation, we examined the phosphorylation status of JNK/SAPK and c-Jun at 18 h after LPS injection. Immunoblot analysis (IB) revealed that LPS increased phosphorylation of JNK/SAPK and c-Jun. Both simvastatin and farnesyltransferase inhibitor, FTI-277, decreased phosphorylation of JNK/SAPK and c-Jun in LPS-administered mice, as compared with vehicle. Neither LPS nor the inhibitors significantly altered the protein expression of JNK/SAPK and c-Jun. **p<0.01 vs without LPS, §p<0.05 vs LPS + vehicle.