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. 2009 Dec 8;102(1):115–123. doi: 10.1038/sj.bjc.6605465

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Copyright © 2010 Cancer Research UK

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Supernatant-stimulated DCs increase the proliferation of T cells in vitro. DCs matured with supernatant (CM) derived from A549 treated with cyclophosphamide (CPM), oxaliplatin (OXP) or gemcitabine (GEM) were admixed with allogeneic T cells loaded with carboxyfluorescein succinimidyl ester (CFSE). (A, B) Proliferation as indicated by a downward shift of CFSE mean fluorescence intensity was increased after culture with the positive control of PHA. Both CD4+ and CD8+ subsets were assessed. (C) There was a trend of increased percentage of proliferating T cells cultured with DCs stimulated with CM, which was significant (P<0.03) in the samples involving GEM. Each data column is a representative of the mean and s.d. of three separate experiments.