Table 3.
Distribution of T cell subsets in peripheral blood from HIV/HTLV-1 co-infected, HIV mono-infected and healthy Mozambican subjects
| T cell subsets and viral load | HIV/HTLV-1 (n = 29) |
HIV (n = 59) |
HC (n = 16) |
|---|---|---|---|
| CD4+ T cell counts (cells/mm3) | |||
| Median | 525a | 274 | 472 |
| IQR | 310 - 827 | 183 - 436 | 412 - 775 |
| CD4+ T cell counts (%) | |||
| Median | 24.9 a, b | 15.9 | 45.0 |
| IQR | 19.0 - 32.7 | 9.4 - 21.0 | 37.0 - 48.0 |
| CD8+ T cell counts, cells/mm3 | |||
| Median | 1002b | 937 | 302 |
| IQR | 649 - 1090 | 606 - 1358 | 190 - 391 |
| CD8+ T cell counts, % | |||
| Median | 46.8a, b | 54.2 | 23.0 |
| IQR | 36.2 - 53.0 | 42.7 - 61.3 | 21.0 - 29.0 |
| CD4+ T/CD8+ T ratio | |||
| Median | 0.5a, b | 0.3 | 1.8 |
| IQR | 0.3 - 0.8 | 0.2 - 0.4 | 1.2 - 2.5 |
| CD8+ CD38+ T cells (MFI) | |||
| Median | 341.5 | 279.9 | 209.7 |
| IQR | 285.1 - 367.1 | 225.4 - 373.3 | 209.7 - 225.4 |
| HIV-1 RNA viral load (copies/mL) | |||
| Median | 56,385 | 37,573 | |
| IQR | 14,749 - 277,570 | 11,322-176,837 |
One ANOVA corrected by Bonferoni was used to compare groups.
HIV/HTLV-1, HIV/HTLV-1 co-infected; HIV, HIV mono-infected; HC, healthy controls; MFI, Median Fluorescence Intensity
a p < 0.05 comparison co-infected versus HIV mono-infected
b p < 0.05 comparison co-infected versus healthy controls