Table 4.
Inference results. Column "Biological Findings" lists a short description of the features of interest and references.
Biological Findings | Observed Genes | Hidden Genes | Inference Results |
---|---|---|---|
Strong relationship between cyclins CLB5 and CLB6 [40] and between CLN1 and CLN2 [41] | CLB5 | CLB6 |
P(CLB6 = 0|CLB5 = 0) = 0.9851 P(CLB6 = 1|CLB5 = 1) = 1.0000 |
CLB6 | CLB5 |
P(CLB5 = 0|CLB6 = 0) = 1.0000 P(CLB5 = 0|CLB6 = 0) = 0.8079 |
|
CLN1 | CLN2 |
P(CLN2 = 0|CLN1 = 0) = 0.95028 P(CLN2 = 1|CLN1 = 1) = 0.8449 |
|
CLN2 | CLN1 |
P(CLN1 = 0|CLN2 = 0) = 0.6111 P(CLN1 = 1|CLN2 = 1) = 0.6111 |
|
Inhibitory activity of SIC1 on cyclins CLB5 and CLB6 [42] | SIC1 | CLB5 | P(CLB5 = 0|SIC1 = 1) = 0.7367 |
CLB6 | P(CLB6 = 0|SIC1 = 1) = 0.7367 | ||
Inactivation of MBP1 and SWI6 causes CLB5 and CLB6 levels to fall [35] | MBP1 | CLB5 | P(CLB5 = 0|MBP1 = 0, SWI6 = 0) = 0.7742 |
SWI6 | CLB6 | P(CLB6 = 0|MBP1 = 0, SWI6 = 0) = 0.8483 | |
While CLN1 and CLN2 are active, SIC1 is degraded [43] | CLN1 | SIC1 | P(SIC1 = 0|CLN1 = 1, CLN2 = 1) = 0.6476 |
CLN2 | |||
Inactivation activity of MBP1 and SWI6 on CLN1 and CLN2 [44] |
MBP1 SWI6 |
CLN1 | P(CLN1 = 0|MBP1 = 1, SWI6 = 1) = 0.6111 |
CLN2 | P(CLN2 = 0|MBP2 = 1, SWI6 = 1) = 0.6148 |
To infer the conditional probability reported in the "Inference Results" column, the sum-product algorithm was used, and the state of the "Observed Genes" is fixed to derive the potential behaviour of "Hidden Genes".