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. 2009 Dec 23;10:444. doi: 10.1186/1471-2105-10-444

Table 4.

Inference results. Column "Biological Findings" lists a short description of the features of interest and references.

Biological Findings Observed Genes Hidden Genes Inference Results
Strong relationship between cyclins CLB5 and CLB6 [40] and between CLN1 and CLN2 [41] CLB5 CLB6 P(CLB6 = 0|CLB5 = 0) = 0.9851
P(CLB6 = 1|CLB5 = 1) = 1.0000

CLB6 CLB5 P(CLB5 = 0|CLB6 = 0) = 1.0000
P(CLB5 = 0|CLB6 = 0) = 0.8079

CLN1 CLN2 P(CLN2 = 0|CLN1 = 0) = 0.95028
P(CLN2 = 1|CLN1 = 1) = 0.8449

CLN2 CLN1 P(CLN1 = 0|CLN2 = 0) = 0.6111
P(CLN1 = 1|CLN2 = 1) = 0.6111

Inhibitory activity of SIC1 on cyclins CLB5 and CLB6 [42] SIC1 CLB5 P(CLB5 = 0|SIC1 = 1) = 0.7367
CLB6 P(CLB6 = 0|SIC1 = 1) = 0.7367

Inactivation of MBP1 and SWI6 causes CLB5 and CLB6 levels to fall [35] MBP1 CLB5 P(CLB5 = 0|MBP1 = 0, SWI6 = 0) = 0.7742
SWI6 CLB6 P(CLB6 = 0|MBP1 = 0, SWI6 = 0) = 0.8483

While CLN1 and CLN2 are active, SIC1 is degraded [43] CLN1 SIC1 P(SIC1 = 0|CLN1 = 1, CLN2 = 1) = 0.6476
CLN2

Inactivation activity of MBP1 and SWI6 on CLN1 and CLN2 [44] MBP1
SWI6
CLN1 P(CLN1 = 0|MBP1 = 1, SWI6 = 1) = 0.6111
CLN2 P(CLN2 = 0|MBP2 = 1, SWI6 = 1) = 0.6148

To infer the conditional probability reported in the "Inference Results" column, the sum-product algorithm was used, and the state of the "Observed Genes" is fixed to derive the potential behaviour of "Hidden Genes".