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. Author manuscript; available in PMC: 2010 Jan 29.
Published in final edited form as: Chem Biol. 2008 Apr;15(4):393. doi: 10.1016/j.chembiol.2008.02.017

Figure 1. Relevant GT-catalyzed coumarin glycosylation reactions.

Figure 1

(A) The reaction catalyzed by WT NovM. (B) The reaction employed for the fluorescence-based screening assay used to evolve OleD. (C) Representation of the novobiocic acid glucosylation reaction catalyzed by WT and variant OleD. (D) The structures of representative naturally-occurring aminocoumarin antibiotics novobiocin (8), clorobiocin (9) and coumermycin A1 (10).