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The key residues delineated in this study are highlighted within the previously reported active site structure of OleD bound to oleandomycin and NDP (PDB file 21YF). Color designations – substrates, orange; Pro-67, red; Ile-112, cyan; Ser-132, magenta; loop N3, yellow; dashed line, H-bond between the catalytic His-25 and acceptor sugar-OH. Residues in green are those that form the acceptor binding pocket, which is largely hydrophobic.
