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. 2010 Feb 1;5(2):e8996. doi: 10.1371/journal.pone.0008996

Figure 5. AMPK activation suppresses L-LTP within a time-restricted window.

Figure 5

A) 5 µM metformin was added 20 minutes prior to TBS and washed out immediately prior to TBS (n = 8). L-LTP at 180 minutes post TBS was equal to control (n = 17), B) metformin was added immediately prior to TBS and washed out immediately after TBS (n = 8). L-LTP was reduced to 30% of control (p = 0.0172). C) metformin was added 5 min after stimulation for the duration of the experiment (n = 5). L-LTP at 180 minutes was indistinguishable from control. Control data in Fig. 5A is reproduced in Fig. 5B and Fig. 5C for comparison. Inset: Representative fEPSP traces shown were taken 4 minutes prior to and 180 minutes after TBS. Error bars show s.e.m.