Table 1. IC50 values for growth inhibitory effect of IC261 in breast cancer cell lines.
Cell line | IC261 IC50 | β-catenin |
MCF7 | 0.5 uM | + |
MDA-MB-453 | 86 uM | - |
BT474 | 6.9 uM | + |
BT549 | 0.9 uM | + |
HS578T | 0.2 uM | + |
SKBR3 | 43 uM | - |
HMEC-hTERT | 46 uM | NA |
IC50 values for each cell line were calculated from a representative experiment performed in triplicate using Graphpad Prism. β-catenin status is indicated in right column.