Fig. 4.
Targeting of VSV to ovarian tumors following IP and IV injection in Wv mice. Four-month-old Wv/Wv mice that bear ovarian tumors were injected IP or IV with 105 pfu of VSV-GFP into the control or Wv/Wv mice. Two mice per experimental group were injected. Ten days after injection, the mice were dissected and organs were examined under fluorescence microscopy for GFP signals. (A) The ovary of a representative tumor-bearing Wv mouse injected IV with VSV shows fluorescence indicating VSV proliferation (arrow). (B) The ovaries from wildtype control mice injected IP with VSV-GFP showed no GPF signal. (C) Other organs from VSV-GFP-injected mice by either IP or IV routes show minimal GFP signals.