Skip to main content
. Author manuscript; available in PMC: 2010 Jan 30.
Published in final edited form as: Steroids. 2009 Oct 7;75(1):1. doi: 10.1016/j.steroids.2009.09.002

Figure 2.

Figure 2

Figure 2

(A) Nucleocytoplasmic shuttling of the glucocorticoid receptor. Upon binding to the ligand, the activated hGRα dissociates from HSPs and translocates into the nucleus, where it homodimerizes and binds to GREs in the promoter region of target genes. (B) Schematic representation of the interaction of AF-1 and AF-2 of hGRα with coactivators. AF: activation function; DRIP/TRAP: vitamin D receptor-interacting protein/thyroid hormone receptor-associated protein; GR: glucocorticoid receptor; GREs: glucocorticoid response elements; HSP: heat shock protein; SWI/SNF: switching/sucrose non-fermenting; TF: transcription factor; TFRE: transcription factor-response element (Adapted from References 78–80).