Schema of study design. At M1, M2 and M3 500 μg subcutaneous doses of HspE7 were administered on alternating thighs. Blood for serology was drawn (solid arrows for cohort 1, dashed arrows for cohort 2) at the enrolment visit (M0), M1 (cohort 2 only). During the study, blood was drawn immediately prior to administration of vaccine dose 2 and 3 (M2 and M3). At M5 or M7 for cohort 1 and cohort 2 respectively, blood was drawn prior to the LEEP procedure. A final blood draw was performed at M12.