Figure 4.

A. Insulin sensitivity test in db₃₃₃/db₃₃₃, db/db and WT mice. Intraperitoneal insulin administration (1 unit per kg of body weight) revealed that both db₃₃₃/db₃₃₃ and db/db mice have an impaired glucose disposal ability relative to the hypoglycemic response to insulin observed in the WT littermates. Data are presented as percentage change in blood glucose from baseline before and after insulin injection for up to 120 mins. B. Intraperitoneal glucose tolerance test in db₃₃₃/db₃₃₃, db/db and WT mice. After glucose challenge db₃₃₃/db₃₃₃ and db/db mice display impaired glucose disposal compared with WT mice. Data are plotted as mean blood glucose ± SE for n = 5 animals of each genotype before and after intraperitoneal glucose injection for up to 120 mins. Significant (P<0.05) differences between db₃₃₃ and WT group means are denoted by asterics and were determined by one way ANOVA and post hoc Tukey test.