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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Biomaterials. 2009 Nov 3;31(6):1372. doi: 10.1016/j.biomaterials.2009.10.045

Figure 2. PKSOD microparticles effectively scavenge extra- and intracellular superoxide.

Figure 2

Superoxide production from phorbol 12-myristate 13-acetate (PMA)-stimulated cultured macrophages was measured by quantitative HPLC. (A) Extracellular superoxide concentration from media per one million cells. Only SOD1 (white bar) and PKSOD were able to significantly reduce PMA-induced extracellular superoxide production in cultured macrophages. (B) Intracellular superoxide per mg protein represented. Only PKSOD significantly reduced the PMA induced intracellular superoxide levels. Results are normalized with respect to control and grouped data are an average of four experiments and shown as mean ± SEM. **p<0.01, ***p<0.001, NS = not significant; ANOVA followed by Tukey-Kramer post-test.