Table 1.
Characterisation of polymer components by weight average and number average molecular weights (Mw and Mn), the degree of functionalisation by hydrazine (CMC) and the degree of oxidation of the dextrans before and after conjugation with amphotericin B.
| Polymer | Mwa (kDa) | Mna (kDa) | NaIO4 (mol %)c | Measured degree of functionalisation |
|---|---|---|---|---|
| CMC | 250b | - | - | - |
| CMC-ADH | 810.3 | 77.7 | - | 51 % |
| Dextran | 100–200b | - | - | - |
| Dextran-CHO33 | 27.6 | 6.8 | 45 | 35 %d |
| Dextran-CHO50 | 21.4 | 5.7 | 64 | 48 %d |
| Dextran-CHO66 | 19.4 | 5.0 | 90 | 66 %d |
| Dextran-CHO75 | 18.0 | 5.0 | 96 | 75 %d |
| Dextran-CHO33-AmB12.5 | 8.0e | 3.1e | - | 15 %d |
| Dextran-CHO33-AmB62.5 | 8.1e | 3.1e | - | 5 %d |
| Dextran-CHO66-AmB62.5 | 7.9e | 2.6e | - | 13 %d |
| Dextran-CHO75-AmB62.5 | 8.3e | 2.5e | - | 18 %d |
a
Relative to Pullulan standards,
b
According to provider,
c
Mol% defined as [IO4-]/[glucose] × 100
d
Number of aldehyde groups per 100 glucose units,
e
Contained multiple components.