Table 3.

Contact Activation of FXII by Incubation with Physical Mixtures of Hydrophilic and Hydrophobic Procoagulants

FXII Lot	w/w Fraction Hydrophilic	Hypothetical Contact Angle (θ) (Degrees)	Hypothetical ${\tau }_n^o$ (dyne/cm)	Average FXIIa Solution Concentration ((PEU/ml) × 10−2, N=2)	Average FXIIa Yield (%, N=2)
1	0.0	117.57	−33.31	3.89 ± 0.61	1.76 ± 0.28
	0.1	108.45	−22.78	4.73 ± 0.73	2.14 ± 0.33
	0.2	99.80	−12.25	3.32 ± 0.53	1.50 ± 0.24
	0.3	91.37	−1.72	3.38 ± 0.54	1.53 ± 0.25
	0.4	82.97	8.80	3.48 ± 0.56	1.57 ± 0.25
	0.5	74.41	19.32	3.59 ± 0.57	1.62 ± 0.26
	0.6	65.48	29.85	4.64 ± 0.72	2.10 ± 0.33
	0.7	55.86	40.38	3.49 ± 0.56	1.58 ± 0.25
	0.8	44.97	50.91	3.31 ± 0.53	1.50 ± 0.24
	0.9	31.38	61.44	3.97 ± 0.63	1.80 ± 0.28
	1.0	0.00	71.97	3.26 ± 0.53	1.48 ± 0.24
2	0.0	118.08	−33.87	3.34 ± 0.53	1.51 ± 0.24
	0.1	110.59	−25.31	3.35 ± 0.54	1.52 ± 0.24
	0.2	101.62	−14.50	3.39 ± 0.54	1.54 ± 0.25
	0.3	92.94	−3.69	2.57 ± 0.43	1.16 ± 0.19
	0.4	84.32	7.11	3.21 ± 0.52	1.45 ± 0.23
	0.5	75.58	17.92	3.03 ± 0.49	1.37 ± 0.22
	0.6	66.47	28.73	2.49 ± 0.41	1.13 ± 0.19
	0.7	56.67	39.54	3.25 ± 0.52	1.47 ± 0.24
	0.8	45.60	50.35	3.46 ± 0.55	1.57 ± 0.25
	0.9	31.80	61.16	2.42 ± 0.40	1.10 ± 0.18
	1.0	0.00	71.97	2.52 ± 0.42	1.15 ± 0.19

Notes: Hydrophilic glass particles (n = 6) mixed with hydrophobic glass particles (n = 12) listed in Table 1. Total procoagulant mass = 100 mg. Hypothetical θ and ${\tau }_n^o$ computed from a linear combination rule (Appendix B). Error in FXIIa concentration is standard deviation of N = 3 measurements with error in percent yield computed by propagation of error. Results obtained with plasma lot II.