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. Author manuscript; available in PMC: 2011 Feb 5.
Published in final edited form as: Org Lett. 2010 Feb 5;12(3):588. doi: 10.1021/ol902784q

Table 2.

Three-Component Coupling of Linchpin 11 with Various Electrophiles

graphic file with name nihms-167148-t0023.jpg
entry electrophile R
1 graphic file with name nihms-167148-t0024.jpg graphic file with name nihms-167148-t0025.jpg
21a: (65%)
2 graphic file with name nihms-167148-t0026.jpg graphic file with name nihms-167148-t0027.jpg
21b: (66%)
3 PhS-SPh graphic file with name nihms-167148-t0028.jpg
21c: (68%)
4 Bu3SnCl graphic file with name nihms-167148-t0029.jpg
21d: (63%)
5 graphic file with name nihms-167148-t0030.jpg graphic file with name nihms-167148-t0031.jpg
21e: (53%)a
6 graphic file with name nihms-167148-t0032.jpg graphic file with name nihms-167148-t0033.jpg
21f: (52%)a
7 graphic file with name nihms-167148-t0034.jpg graphic file with name nihms-167148-t0035.jpg
21g: (54%)a
8 graphic file with name nihms-167148-t0036.jpg graphic file with name nihms-167148-t0037.jpg
21h: (61%)a

Conditions: 1.2 equiv n-BuLi, 1.2 equiv CuI.

a

3 mol % Pd(PPh3)4, THF, rt, 6 h.