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. Author manuscript; available in PMC: 2011 Feb 5.
Published in final edited form as: Org Lett. 2010 Feb 5;12(3):588. doi: 10.1021/ol902784q

Table 4.

Three-Component Coupling of Linchpin 12 with Various Electrophiles

graphic file with name nihms-167148-t0050.jpg
entry electrophile R
1 graphic file with name nihms-167148-t0051.jpg graphic file with name nihms-167148-t0052.jpg
23a: (49%)
2 graphic file with name nihms-167148-t0053.jpg graphic file with name nihms-167148-t0054.jpg
23b: (42%)
3 PhS-SPh graphic file with name nihms-167148-t0055.jpg
23c: (52%)
4 graphic file with name nihms-167148-t0056.jpg graphic file with name nihms-167148-t0057.jpg
23d: (51%)
5 graphic file with name nihms-167148-t0058.jpg graphic file with name nihms-167148-t0059.jpg
23e: (45%)a
6 graphic file with name nihms-167148-t0060.jpg graphic file with name nihms-167148-t0061.jpg
23f: (44%)a

Conditions: 2.0 equiv n-BuLi, 2.0 equiv CuI.

a

3 mol % Pd(PPh3)4, THF, rt, 12 h.