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. 2009 Nov 4;35(3):702–719. doi: 10.1038/npp.2009.178

Table 5. Identified Common and Specific Pathways for Each Smoking Behavior Category.

Pathways Smoking initiation and progression Nicotine dependence Smoking cessation
Calcium signaling + + +
cAMP-mediated signaling + + +
Dopamine receptor signaling + + +
G-protein-coupled receptor signaling + + +
Serotonin receptor signaling + +
Tryptophan metabolism + +
Gap junction + +
Neurotrophin/TRK signaling + +
Synaptic long-term potentiation + +
Tyrosine metabolism + +
Integrin signaling +
Tight junction signaling + +
Arachidonic acid metabolism +
Fatty acid metabolism +
GABA receptor signaling +
Histidine metabolism +
Linoleic acid metabolism +
LPS/IL-1-mediated inhibition of RXR function +
MAPK signaling pathway +
Metabolism of xenobiotics by cytochrome P450 +
Phenylalanine metabolism +
PXR/RXR activation +
Regulation of actin cytoskeleton +
Amyotrophic lateral sclerosis signaling +
Circadian rhythm signaling +
Glutamate receptor signaling +
Synaptic long-term depression +