Fig. 1.

Dietary intervention protocols in breeding pairs and their female offspring. To establish a low-diabetogenic diet (a), breeding pairs were fed either diet B or diet C and groups of randomized female offspring received diets with different protein sources. To investigate the effects of individual food components on diabetes development, 2 food groups were analyzed (b). All breeding pairs were fed diet C without supplements. In dietary intervention protocol B1, groups of female offspring received diet C supplemented with varying amounts of whole wheat or wheat protein fractions, to analyze the effects of wheat proteins. In dietary intervention protocol B2, groups of female offspring received diet C supplemented with selected single foods, to analyze effects of foods introduced into early infant diet. For both dietary intervention protocols, 1 group of mice fed with diet C without supplements was used as control group.