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Proportion of children with positive reactivities of antibody isotypes IgG1, IgG2, IgG3, IgG4, IgM and IgA to antigens at ages 0, 4, 9, 18 and 36 months. Each line represents the change in proportions of children with positive reactivities (ELISA OD >mean + 3 SD of negative control sera panel) against specific antigens at different ages.
