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Mutational hotspots in EGFR gene clustering at ATP-binding pocket. The above sequences contain the 2 primary sites of interest for mutation analysis. The areas in red represent the regions where mutations most often occur. The mutation in exon 19 is most commonly a deletion mutation, while the mutation seen in exon 21 is a missense mutation (T → G substitution at nucleotide 2573 resulting in a L858R amino acid substitution).
